neuropathy diabetes pathophysiology - Diabetic neuropathy DN is the most daun kemangi untuk obat diabetes common form of neuropathy in developed countries and may affect about half of all patients with diabetes DM contributing to substantial morbidity and mortality and resulting in a huge economic burden DN encompasses multiple different disorders involving proximal distal somatic and autonomic nerves It may be acute and selflimiting or a chronic Before attributing a neuropathy to diabetes mellitus a careful clinical history and investigation should be performed to exclude other potential causes for example thyroid disease vasculitis Oxidative stress metabolic abnormalities microangiopathy and other factors caused by diabetes through special signal transduction pathways destroy the normal structure and function of nerve cells and lead to neuronal demyelination and neuronal damage which are the main causes of peripheral neuropathy 34 35 Pathogenesis diagnosis and clinical management of diabetic Peripheral neuropathy encompasses a broad range of clinical pathologies potentially presenting with peripheral nervous system dysfunction1 Patients with peripheral neuropathy often present with varying degrees of numbness tingling aching burning sensation weakness of limbs hyperalgesia allodynia and pain This pain has been characterized as superficial deepseated or severe Abstract Neuropathy is the most common complication of diabetes As a consequence of longstanding hyperglycemia a downstream metabolic cascade leads to peripheral nerve injury through an increased flux of the polyol pathway enhanced advanced glycation endproducts formation excessive release of cytokines activation of protein kinase C and exaggerated oxidative stress as well as other Diabetic neuropathy PMC Diagnosis and Treatment of Painful Diabetic Peripheral Neuropathy Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes which affects over 90 apakah diabetes boleh merokok of the diabetic patients what can also be implicated in the pathophysiology of diabetic neuropathy and then in the DNP It is believed that one potential cause of the microvascular changes described above may be the oxidative stress ing of the pathophysiology of diabetic neuropathy highlighting the mechanisms underlying nerve damage and dysfunction in the context of diabetes mellitus In this review of the current evidence we will discuss the molecular cellular and systemic factors that contribute to the development and progression of diabetic neuropathy Diabetic Neuropathy Pathophysiology Review PubMed Mechanism of diabetic neuropathy Where are we now and where to go Diabetic Peripheral Neuropathy StatPearls NCBI Bookshelf PDF Diabetic Neuropathy Pathophysiology Review Springer Mechanismspathophysiology Diabetic neuropathy is a unique neurodegenerative disorder of the peripheral nervous system that preferentially targets sensory axons autonomic axons and later to a lesser extent motor axons How diabetes mellitus targets sensory neurons remains debated Progressive diabetic neuropathy involves retraction and Diabetic neuropathy may cause a range of symptoms including pain numbness muscle weakness autonomic dysfunction and foot ulcers potentially causing significant impairment to the quality of life for those affected This review article aims to provide a comprehensive overview of the pathophysiology of diabetic neuropathy Between 1970 to 2010 studies aiming to understand the pathophysiology of diabetic neuropathy focused on glucose dysregulation In the polyol pathway aldose reductase converts excess glucose to sorbitol resulting in a series of downstream reactions that decrease sodiumpotassium adenosine triphosphatase ATP activity deplete nicotinamide Diabetic Neuropathies Endotext NCBI Bookshelf Diabetic neuropathic pain Physiopathology and treatment Frontiers Diabetic peripheral tortillas and diabetes neuropathy pathogenetic mechanisms and
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