streptozotocin induced diabetes in rats - Challenges and issues with streptozotocininduced diabetes hibest propolis diabetes A Streptozotocin STZ is a widely used chemical for the induction of experimental diabetes in rodents 4 5 Since the initial report of its diabetogenic properties in 1963 6 STZ has been used alone or in combination with other chemicals or with dietary manipulations for induction of either type 1 or type 2 diabetes 7 8 Type 1 diabetes can be StreptozotocinInduced Diabetic Models in Mice and Rats StreptozotocinInduced Diabetic Models in Mice and Rats An example of an experimentallyinduced animal model of diabetes is the highfat dietstreptozotocin treated HFDSTZ rat model This model involves a combination of a diet high in fat and in some cases sugar to bring about hyperinsulinemia insulin resistance andor glucose intolerance followed by treatment with the βcell toxin STZ This review aimed to gather information about pathophysiological mechanisms and fetal outcomes in streptozotocininduced diabetic rats To understand the pathophysiological mechanisms and factors involved in diabetes the use of pancreatic regeneration studies is increasing in an attempt to understand the behavior of pancreatic beta cells Streptozotocin STZ is an antibiotic that can cause pancreatic βcell destruction so it is widely used experimentally as an agent capable of inducing insulindependent diabetes mellitus IDDM also known as type 1 diabetes mellitus T1DM This unit describes protocols for the production of insulin deficiency and hyperglycemia in mice and Induction of diabetes by Streptozotocin in rats PMC STZinduced diabetes in rats is a valuable tool for diabetes research which has been used by many investigators 129 However STZdiabetes is multifactorial and depends on various practical aspects such as stability of STZ animal species strain gender age route of administration and dosage 130 Streptozotocin as a tool for induction of rat models of diabetes a A practical guide for induction of diabetes 中文 type2 diabetes in rat Abstract Streptozotocin STZ is the most used diabetogenic chemical for creating rat models of type 1 and type 2 diabetes Despite 60 years of using STZ in animal diabetes research some prevailing views about STZ preparation and use are not supported by evidence Here we provide practical guides for using STZ to induce diabetes in rats The aim of this review is to present features of a frequently used model of type2 diabetes in rat induced by a high fat diet and streptozotocin taking into account its advantagesdisadvantages and presenting a practical guide Myoinositol ameliorates highfat diet and streptozotocininduced diabetes in rats through promoting insulin Streptozotocininduced diabetic models in mice and rats Streptozotocin STZ is an antibiotic that causes pancreatic islet βcell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus T1DM Detailed in this article are protocols for producing STZinduced insulin deficiency and hyperglycemia in mice and rats Also described are protocols for creating animal StreptozotocinInduced Diabetes Models Pathophysiological Mechanisms Modeling type 2 diabetes in rats using high fat diet and streptozotocin Basic Protocol 2 STREPTOZOTOCININDUCED TYPE 1 DIABETES MELLITUS IN RATS The rat is commonly used as an STZinduced diabetic model As in the mouse the production of a diabetic state in rats is dependent on the dose of STZ Arison Ciaccio Glitzer Cassaro Pruss 1967 Ganda Rossini Like 1976 Junod et al 1969 For induction of experimental diabetes in male adult rats weighted 250300 grams 7590 days 60mgkg of Streptozotocin was injected intravenously Three days after degeneration of beta cells diabetes was induced in all animals The diabetic and normal animals were kept in the metabolic cages separately and their body weight consumption Streptozotocininduced type 1 diabetes in rodents tertiary prevention diabetes as a model for
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