streptozotocin induksi diabetes - This review aimed to gather information autoimun diabetes tipe 1 about pathophysiological mechanisms and fetal outcomes in streptozotocininduced diabetic rats To understand the pathophysiological mechanisms and factors involved in diabetes the use of pancreatic regeneration studies is increasing in an attempt to understand the behavior of pancreatic beta cells Induction of diabetes by Streptozotocin in rats PMC StreptozotocinInduced Diabetes Models Pathophysiological Mechanisms Alternate Protocol INDUCTION OF TYPE 1 DIABETES MELLITUS IN MICE USING A SINGLE HIGH DOSE OF STREPTOZOTOCIN A single high dose of STZ 200 mgkg is directly toxic to pancreatic βcells rapidly causing diabetes with blood glucose concentrations of 500 mgdl within 48 hr Like Rossini 1976Although multiple low doses of STZ are associated with fewer toxic effects than a single StreptozotocinInduced Diabetic Models in Mice and Rats The main cause of morbidity and mortality in diabetes mellitus DM is cardiovascular complications Diabetic cardiomyopathy DCM remains incompletely understood Animal models have been crucial in exploring DCM pathophysiology while identifying potential therapeutic targets Streptozotocin STZ h Patients with diabetes mellitus have a 2to4fold higher risk of ischemic disease than their nondiabetic counterparts In individuals with type 1 diabetes the risk appears to be even higher Platelet hyperreactivity has been postulated as a potential contributor to the increased thrombogenicity observed in the diabetic population Streptozotocin STZ is an antibiotic that causes pancreatic islet βcell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus T1DM Detailed in this article are protocols for producing STZinduced insulin deficiency and hyperglycemia in mice and rats Also Streptozotocininduced diabetes models pathophysiological mechanisms In mice which represent the second most commonly used penderita diabetes membatasi mengonsumsi makanan yang mengandung animal species for streptozotocininduced diabetes several connections can be found in relation to the rat model of streptozotocin diabetes Namely both intravenous and intraperitoneal applications of streptozotocin have been described Wang et al 2012 Wang et al 2015 StreptozotocinInduced Type 1 and 2 Diabetes Mellitus Mouse PubMed Streptozotocin STZ was first isolated from a soil microorganism Streptomyces acromogenes and showed broad spectrum antibiotic activity 1Since its discovery in 1959 STZ has been widely used for the induction of diabetes in experimental animals and in preclinical studies 2Among several available chemicals used to induce diabetes STZ is most preferred to model human diabetes in animals Streptozotocin is an antimicrobial agent and has also been used as a chemotherapeutic alkylating agent Streptozotocin diabetes is caused by the specific necrosis of the pancreatic βcells and this agent is the first choice for diabetes induction in animals 69 70 Experimental diabetes induced by alloxan and streptozotocin The Single Dose Streptozotocin Induced Diabetes Considerations for Study StreptozotocinInduced Diabetic Models in Mice and Rats Challenges and issues with streptozotocininduced diabetes A Low dose streptozotocin causes diabetes in severe combined immunodeficient SCID mice without immune cell infiltration of the pancreatic islets Autoimmunity 19952028392 doi 10310908916939509001931 Google Scholar 37 Cossel L Schneider E Kuttler B Schmidt S Wohlrab F Schade J et al Low dose streptozotocin induced diabetes Streptozotocininduced Diabetes Mellitus a Paradox of High Intrinsic Streptozotocin induces one type of diabetes which is similar to diabetes mellitus with nonketosis hyperglycemia in some animal species For induction of experimental diabetes in male adult rats weighted 250300 grams 7590 days 60mgkg of diabetes makan jengkol Streptozotocin was injected intravenously
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