type 1 diabetes is caused by a mutated gene - Diabetes is a chronic metabolic disorder jelaskan patofisiologi diabetes melitus that adversely affects the bodys ability to manufacture and use insulin a hormone necessary for the conversion of food into energy The disease greatly increases the risk of blindness heart disease kidney failure neurological disease and other conditions for the approximately 16 million Americans who are affected by it Type 1 or juvenile onset Diabetes type 1 Genes and Disease NCBI Bookshelf Current understandings of the pathogenesis of type 1 diabetes Genetics Candidate genes for type 1 diabetes Susceptibility to T1D is strongly associated with a genetic background GWAS contributed to the discovery of a number of T1D susceptibility genes Before GWAS only five loci were determined as associated with T1D They were in that order HLA region INS CTLA4 PTPN22 and IL2RA Genetics of Type 1 Diabetes PubMed Created July 7 2004 Type 1 diabetes is an autoimmune disorder in which the body attacks its pancreatic beta cells The onset of type 1 diabetes is attributed to both an inherited risk and external triggers such as diet or an infection The hunt for these genetic and enviromental risk factors is ongoing Type 2 diabetes has a stronger link to family history and lineage than type 1 and studies of twins have shown that genetics play a very strong role in the development of type 2 diabetes Race can also play a role Yet it also depends on environmental factors Lifestyle also influences the development of type 2 diabetes Type 1 diabetes Symptoms and causes Mayo Clinic Type 1 diabetes once known as juvenile diabetes or insulindependent diabetes is a chronic condition In this condition the pancreas makes little or no insulin Insulin is a hormone the body uses to allow sugar glucose to enter cells to produce energy Different factors such as genetics and some viruses may cause pharmacological treatment for type 2 diabetes type 1 diabetes Genetics of Type 1 Diabetes Diabetes in America NCBI Bookshelf Type 1 diabetes a multifactorial disease with a strong genetic component is caused by the autoimmune destruction of pancreatic β cells The major susceptibility locus maps to the HLA class II genes at 6p21 although more than 40 nonHLA susceptibility gene markers have been confirmed Is Diabetes Genetic The Hereditary Risk of Type 1 Diabetes WebMD Chapter 2 Genetic Factors in Type 1 Diabetes National Center for Ancestryspecific genetic associations of type 1 diabetes have emerged The majority of nonMHC variants are in noncoding sequences and most likely affect gene regulation rather than directly altering protein structure In addition to genetic factors epigenetic changes in the genome are implicated in type 1 diabetes Type 1 diabetes genes associated with disease development Type 1 diabetes T1D is an autoimmune disease that usually strikes early in life but can affect individuals at almost any age It is caused by autoreactive T cells that destroy insulinproducing beta cells in the pancreas Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2 1 If the parent had diabetes before age 11 the childs chances double 2 If both parents have it the odds could be as high as 1 in 4 3 If the parent also has a condition called type 2 Genetics of Type 1 Diabetes PMC PubMed Central PMC Type 1 diabetes is a complex disease that has both genetic and environmental determinants Based on twin and family studies from largely Europeanancestry populations the estimated contribution of genetic factors to type 1 diabetes risk is 50 Genes and their variants within the human major histocompatibility complex MHC the human leukocyte antigen HLA loci including class I HLAA Genetics of 73rd scientific sessions of the american diabetes association restorative yoga Diabetes American Diabetes Association
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